Long term association between clinical features and the progress of Alzheimer's Lead Investigator: Fangyao Chen Institution : Xi'an Jiaotong University Health Science Center E-Mail : chenfy@xjtu.edu.cn Proposal ID : 1235 Proposal Description: This work will focus on the identification of long term association between clinical features and AD. The status and progressing trends of depressive symptom, cognitive function between individual with and without AD and other chronic diseases. We would also like to investigate the progressing trends of AD between patients with different clinical status. A machine learning based screening approach will be conducted to select possible for early predictive indicators/features for AD.